Beta-Blockers Nonselective: May diminish the bronchodilatory effect of Theophylline Derivatives. Moderate. These medicines may cause some risk when taken together. Children up to age 4 are usually treated a little differently than those 5 to 11 years old. can buy fenofibrate walgreens
The of adverse events reported by patients in multiple-dose clinical trials, without regard to drug relationship, was 23%. The incidence of drug-related adverse reactions in multiple-dose clinical trials was 16%. Human experience of acute overdose with zileuton is limited. Consider 10% decrease in dose to provide greater margin of safety even if current dosage is tolerated. The effect of food on the of enoxacin from the tablet formulation has not been studied.
Follow the directions on your prescription label. Do not take theophylline in larger or smaller amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results. Stop infusion for 12 hours and decrease subsequent infusion rate at least 25%. If symptomatic, stop infusion and consider whether overdose treatment is indicated. ZYFLO activity is primarily due to the parent drug. Cardiovascular side effects have included increases in heart rate which have progressed to supraventricular tachycardia or ventricular tachycardia. Patients with a history of arrhythmias may be predisposed to this effect. Hypotension has occurred with rapid intravenous administration.
Blue No. 2 lake, hydroxypropyl cellulose NF, hydroxypropyl methylcellulose, stearate USP, polyethylene glycol, simethicone, sorbic acid, stearate emulsifiers, and titanium dioxide. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Store at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Keep all medicines away from children and pets.
Get medical help right away if your asthma symptoms worsen or if you are using your quick-relief inhaler more than usual or more often than prescribed. Congestive Heart Failure CHF: Theophylline clearance is decreased by 50% or more in patients with CHF. The extent of reduction in Theophylline clearance in patients with CHF appears to be directly correlated to the severity of the cardiac disease. Since Theophylline clearance is independent of liver blood flow, the reduction in clearance appears to be due to impaired hepatocyte function rather than reduced perfusion. Fever, regardless of its underlying cause, can decrease the clearance of theophylline. The magnitude and duration of the fever appear to be directly correlated to the degree of decrease of theophylline clearance. There are many triggers that may initiate the release of inflammatory substances. Lithium dose required to achieve a therapeutic serum concentration increased an average of 60%. Dosing Guidelines, Table VI. What is theophylline Uniphyl? Who should not take ZYFLO? Enoxacin is an inhibitor of the enzyme gyrase and is a bactericidal agent. Enoxacin may be active against pathogens resistant to drugs that act by different mechanisms. Case reports of theophylline overdose in humans and animal studies suggest that phenytoin is ineffective in terminating theophylline-induced seizures. The doses of benzodiazepines and phenobarbital required to terminate theophylline-induced seizures are close to the doses that may cause severe respiratory depression or respiratory arrest; the clinician should therefore be prepared to provide assisted ventilation. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Barbiturate-induced coma or administration of general anesthesia may be required to terminate repetitive seizures or status epilepticus. General anesthesia should be used with caution in patients with theophylline overdose because fluorinated volatile anesthetics may sensitize the myocardium to endogenous catecholamines released by theophylline. Enflurane appears less likely to be associated with this effect than halothane and may, therefore, be safer. Neuromuscular blocking agents alone should not be used to terminate seizures since they abolish the musculoskeletal manifestations without terminating seizure activity in the brain. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Table IV. Manifestations of theophylline toxicity. Berlinger WG, Spector R, Goldberg MJ, Johnson GF, Quee CK, Berg MJ. Enhancement of theophylline clearance by oral activated charcoal. You might wonder, is asthmatic bronchitis contagious?
The listing of drugs in Tables II and III are current as of June, 1996. Theophylline clearance are continued. Phenobarbital may cause respiratory depression, particularly in elderly patients and patients with COPD. If you suspect that certain foods are for you, discuss this with your doctor. can be done to determine if you are allergic to these foods. What Do I Do If I Have Food Allergies and Asthma? Taking Theophylline extended-release tablets immediately after a high-fat content meal may result in a somewhat higher C max and delayed T max and somewhat greater extent of absorption. Increased risk of ventricular arrhythmias. Jain R, Tholl DA. Activated charcoal for theophylline toxicity in a premature infant on the second day of life. Inhaled steroids are first-line anti-inflammatory therapy. Examples of these medications include budesonide Pulmicort fluticasone Flovent beclomethasone Qvar mometasone Asmanex and ciclesonide Alvesco. Theophylline concentration in the pharmacologically active unbound form. Iobenguane I 123: Sympathomimetics may diminish the therapeutic effect of Iobenguane I 123. Consider extracorporeal removal, even if the patient has not experienced a seizure see OVERDOSAGE, Extracorporeal Removal. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. There are many reasons why people have trouble taking their medicine. Decreases theophylline clearance and pharmacologic interaction. P-450 1A2 and 3A3 activity. Theophylline Tablets are not to be chewed or crushed because it may lead to a rapid release of Theophylline with the potential for toxicity. The scored tablet may be split. Patients receiving Theophylline tablets may pass an intact matrix tablet in the stool or via colostomy. These matrix tablets usually contain little or no residual Theophylline. Combining guarana with polyphenols may have a similar effect. The safety of using guarana for weight loss is unknown. lisinopril
Consider extracorporeal removal even if the patient has not experienced a seizure see OVERDOSAGE, Extracorporeal Removal. The exact relationship of these and other factors to nighttime serum concentrations and the clinical significance of such findings require additional study. Therefore, it is not recommended that Theo-24 when used as a once-a-day product be administered at night. Mayo Clinic: “Cellulite Treatment. Vesicant; ensure proper needle or catheter placement prior to and during IV infusion. Avoid extravasation. Inform your doctor if your condition persists or worsens. Minton NA, Henry JA. Prevention of drug absorption in simulated theophylline overdose. Sulfinpyrazone: May decrease the serum concentration of Theophylline Derivatives. This group of medications includes and . These medications may be used alone in milder asthma but are often used along with inhaled corticosteroids in moderate to severe asthma. Feeling good is a sign that the medicine is working. When dosing was done under fed conditions, the subjects received a standard breakfast consisting of 2 fried eggs, 2 strips of bacon, 4 oz. hash brown potatoes, 1 slice of toast with a pat of butter, and 8 oz. whole milk 15 minutes pre-dosing. No food was allowed for five hours post-dosing, then a standard lunch was served; at ten hours post-dosing a standard supper was served. COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. If symptoms are not controlled and current dosage is tolerated consider adding additional medications to treatment regimen. What are the possible side effects of ZYFLO? cheapest furosemide order payment europe furosemide
Helliwell M, Berry D. Theophylline absorption by effervescent activated charcoal Medicoal. Increase Theophylline clearance by increasing demethylation and hydroxylation. Decreases renal clearance of Theophylline. Allopurinol: May increase the serum concentration of Theophylline Derivatives. Table III. Drugs that have been documented not to interact with Theophylline or drugs that produce no clinically significant interaction with Theophylline. Postural drainage is getting in positions that make it easier for mucus to drain. Usually the benefits of the medicine are more important than any minor side effects. price of geodon in singapore
Central nervous system: Theophylline-induced nonconvulsive status epilepticus has been reported rarely and should be considered in patients who develop CNS abnormalities. Mohsenifar Z, Lehrman S, Carson SA, Tashkin D "Two cases of allergy to aminophylline. American Academy of Cosmetic Surgery: “Reality Vs Myth. Serious adverse effects in the infant are unlikely unless the mother has toxic serum theophylline concentrations. This is not a complete list of side effects and others may occur. There was no significant interaction between ZYFLO and any of these drugs. Theophylline may also be used for purposes not listed in this medication guide. The dose of your medicine may need to be adjusted. Get medical help right away if your worsen or if you are using your quick-relief more than usual or more often than prescribed. Theophylline clearance may be further reduced by concomitant diseases prevalent in the elderly, which further impair clearance of this drug and have the potential to increase serum levels and potential toxicity. These conditions include impaired renal function, chronic obstructive pulmonary disease, congestive heart failure, hepatic disease and an increased prevalence of use of certain medications see with the potential for pharmacokinetic and pharmacodynamic interaction. Protein binding may be decreased in the elderly resulting in an increased proportion of the total serum theophylline concentration in the pharmacologically active unbound form. Elderly patients also appear to be more sensitive to the toxic effects of theophylline after chronic overdosage than younger patients. Quinolone Antibiotics: May decrease the metabolism of Theophylline Derivatives. Ciprofloxacin and enoxacin are of greatest concern. Interpretation involves the correlation of the diameter obtained in the disk test with the minimum inhibitory concentration MIC for enoxacin. Because caffeine is a stimulant that has been shown to improve mood and aid weight loss, guarana may very well also have these effects. money order cheap digoxin otc digoxin
Still have major difficulty breathing despite using both an inhaled beta2-agonist and an inhaled anticholinergic. How should I take theophylline Uniphyl? Phenobarbital may cause respiratory depression, particularly in elderly patients and patients with COPD. Get medical help right away if you have any very serious side effects, including: seizures. Estrogen Derivatives: May increase the serum concentration of Theophylline Derivatives. Goldberg MJ, Spector R, Park GD, Johnson GF, Roberts P. The effect of sorbitol and activated charcoal on serum theophylline concentrations after slow-release theophylline. Side effects may go away after you take the medicine for a while. Uniphyl theophylline anhydrous tablet Tablets whether dosed in the morning or evening. Other manifestations of Theophylline toxicity include increases in serum calcium, creatine kinase, myoglobin and leukocyte count, decreases in serum phosphate and magnesium, acute myocardial infarction, and urinary retention in men with obstructive uropathy. Leukotriene modifiers can also serve as anti-inflammatory agents. These medications include montelukast Singulair zafirlukast Accolate and zileuton Zyflo. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. COPD treatment: Theophylline is currently considered second-line intravenous therapy in the emergency department or hospital setting when there is inadequate or insufficient response to short acting bronchodilators Global Initiative for COPD Guidelines 2013. Use ideal body weight for obese patients. Phenytoin increases Theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin absorption. Higher doses of Theophylline may be required to achieve desired effect. The pharmacokinetics of Theophylline vary widely among similar patients and cannot be predicted by age, sex, body weight or other demographic characteristics. In addition, certain concurrent illnesses and alterations in normal physiology see Table I and co-administration of other drugs see Table II can significantly alter the pharmacokinetic characteristics of Theophylline. Within-subject variability in metabolism has also been reported in some studies, especially in acutely ill patients.
The patient should be instructed to contact their clinician if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another clinician adds a new medication or discontinues a previously prescribed medication. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose. Children 6-15 years and adults 16-60 years without risk factors for impaired clearance. Disulfiram: May increase the serum concentration of Theophylline Derivatives. Do not start or stop smoking without first talking to your doctor. changes the way your body uses theophylline, and you may need to use a different dose. Taniguchi A, Ohe T, Shimorura K "Theophylline-induced ventricular tachycardia in a patient with chronic lung disease: sensitivity to verapamil. sfil.info plaquenil
In neonates, approximately 50% of the theophylline dose is excreted unchanged in the urine. Beyond the first three months of life, approximately 10% of the theophylline dose is excreted unchanged in the urine. Some medicines can harm your baby. If symptomatic, consider whether overdose treatment is indicated see recommendations for chronic overdosage. Before making a dose increase to determine whether the serum concentration is sub-therapeutic in a patient who continues to be symptomatic. What should I discuss with my healthcare provider before taking theophylline Uniphyl? Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone. Metabolic side effects have included hypokalemia, hyperglycemia, respiratory alkalosis, hypophosphatemia, and hypomagnesemia, especially in the situation of acute overdosage. The magnitude of these abnormalities have been correlated with theophylline concentrations. Hypercalcemia has been reported in a patient with hyperthyroid disease with theophylline at therapeutic concentrations. Drug Interactions with the potential for pharmacokinetic and pharmacodynamic interaction. Protein binding may be decreased in the elderly resulting in an increased proportion of the total serum Theophylline concentration in the pharmacologically active unbound form. Elderly patients also appear to be more sensitive to the toxic effects of Theophylline after chronic overdosage than younger patients. Theo-24 is contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product. Theophylline has two distinct actions; smooth muscle relaxation ie, bronchodilation and suppression of the response of the airways to stimuli ie, non-bronchodilator prophylactic effects. Bronchodilation is mediated by inhibition of two isoenzymes, phosphodiesterase PDE III and, to a lesser extent, PDE IV while non-bronchodilation effects are mediated through other molecular mechanisms. Theophylline increases the force of contraction of diaphragmatic muscles through enhancement of calcium uptake through adenosine-mediated channels. Theophylline extended-release tablets were administered with and without food. Subjects were fasted overnight and received a single 300 mg tablet early the following morning. Refer to PRECAUTIONS, Drug Interactions for further information regarding table. Average effect on steady state theophylline concentration or other clinical effect for pharmacologic interactions. Individual patients may experience larger changes in serum theophylline concentration than the value listed. Patients with more rapid metabolism clinically identified by higher than average dose requirements, should receive a smaller dose more frequently every 12 hours to prevent breakthrough symptoms resulting from low trough concentrations before the next dose. TABLE VI. Dosage adjustment guided by serum theophylline concentration. Tell your doctor if you smoke or if you have recently stopped smoking. Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin absorption. Drug Interactions Theophylline interacts with a wide variety of drugs. purchase generic cefadroxil pharmacy
Medicines and illnesses can affect how quickly theophylline is cleared from the body. So the amount of theophylline in the must be measured regularly to be sure it stays at a safe level. Pharmacokinetic differences in theophylline clearance due to race have not been studied. Uniphyl theophylline anhydrous tablet be taken with meals. Administer multiple-dose oral activated charcoal and measures to control emesis. Charcoal must be retained in, and pass through, the gastrointestinal tract to be effective; emesis should therefore be controlled by administration of appropriate antiemetics. Alternatively, the charcoal can be administered continuously through a nasogastric tube in conjunction with appropriate antiemetics. A single dose of sorbitol may be administered with the activated charcoal to promote stooling to facilitate clearance of the adsorbed theophylline from the gastrointestinal tract. Sorbitol alone does not enhance clearance of theophylline and should be dosed with caution to prevent excessive stooling which can result in severe fluid and electrolyte imbalances. Commercially available fixed combinations of liquid charcoal and sorbitol should be avoided in young children and after the first dose in adolescents and adults since they do not allow for individualization of charcoal and sorbitol dosing. Table I. Mean and range of total body clearance and half-life of theophylline related to age and altered physiological states. If you do not have a dose-measuring device, ask your pharmacist for one. Skip next dose and decrease subsequent doses at least 25% even if no adverse effects are present. Recheck serum concentration after 3 days to guide further dosage adjustment. If symptomatic, consider whether overdose treatment is indicated see recommendations for chronic overdosage. Use with caution and monitor serum theophylline concentrations frequently. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. Do not take these medications without talking to your doctor; they can increase the side effects of theophylline. If any of these effects persist or worsen, tell your doctor or promptly. Theophylline only rarely alters the pharmacokinetics of other drugs. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. where can you get indocin
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Monitor the patient and obtain serial theophylline concentrations every 2-4 hours to gauge the effectiveness of therapy and to guide further treatment decisions. Frequency not defined. Adverse events observed at therapeutic serum levels. Theolair theophylline tablets 250" on the other. Not reported in a comparable manner. xeloda
Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose. Theophylline clearance is decreased by 50% or more in patients with CHF. Elevated serum CK-MB levels have been associated with theophylline toxicity in the absence of cardiac disease. CK-MB levels have returned to normal following discontinuation of theophylline therapy. Combination controller medications exist for patients whose asthma symptoms are not well controlled on inhaled corticosteroids alone. money order benicar store
Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while Theophylline blocks adenosine receptors. Propylene glycol: Some dosage forms may contain propylene glycol; large amounts are potentially toxic and have been associated hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution AAP, 1997; Zar 2007. AUC and consequent increased beta-blocker activity. Always consult a healthcare professional for medical advice. Caffeine may increase some of the side effects of theophylline.
Barry M, Feely J. Allopurinol influences aminophenazone elimination. Some believe that the effects of guarana are less intense and longer-lasting than caffeine. Studies have not established this. How much guarana should you take? How should I take theophylline? can you buy meclizine over counter